Multicenter funded study to estimate CVD risk in pregnant women and their infants

A collaboration between the departments of Obstetrics and Gynecology, Emergency Medicine, and Exercise and Sports Sciences received a $ 2.75 million grant through the Center for Women’s Health Research at the ‘UNC to understand early detection of subclinical disease – key to CVD risk stratification and prevention.


Kim Boggess, MD, (Obstetrics and Gynecology) and Michelle Meyer, PhD, MPH, (Emergency Medicine) as well as Lee Stoner, PhD, MPH, MA, (Exercise and Sports Science) and Marcella Boynton, PhD, (Medicine internal) received an R01 of $ 2.75 million through the UNC Women’s Health Research Center to conduct a prospective multicenter study to estimate the risk of cardiovascular disease (CVD) in healthy and medically complicated pregnant women and their infants. This study represents a partnership between the departments of Obstetrics and Gynecology, Emergency Medicine, and Exercise and Sport Science to understand the early detection of subclinical disease – key to risk stratification and prevention. MCV. Since prenatal and postpartum care is the only point of access to health care for most American women, pregnancy represents a critical opportunity to measure CVD risk and implement innovative strategies to address this risk. critical gap in women’s health care. Additionally, CVD risk factor trajectories begin in utero and early in life, so pregnancy is also an opportunity to identify CVD risk in children.

Their long-term goal is to identify and disseminate obstetric care practices that reduce the risk of CVD for women and their children. The objective of this prospective multicenter study on the determinants of vascular aging in mother and infant (MIDAS) is to estimate the risk of CVD in 840 healthy and medically complicated pregnant women and their infants from birth to 18 months. postpartum. The primary outcomes are maternal and infant central pulse wave velocity (PWV), a validated measure of arterial stiffness (vascular aging) that predicts CVD, independent of other established CVD risk factors. The project will also examine the relationships between personal, social and ecological factors and CVD risk for 18 months after childbirth. Study sites include UAB Birmingham and Columbia University.

The results of this research will inform future studies on CVD screening strategies to identify the mother / child dyads most at risk for early arterial stiffness, a harbinger of CVD later in life. This proposal represents a paradigm shift in antenatal care, laying the groundwork for using pregnancy as an opportunity to identify and modify CVD risk in mother / child dyads. This study would be the first to assess the association of arterial stiffness in a diverse population of mother / child dyads.

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