Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies in blood donors: a scoping review

This article was originally published here

Vox sang. Dec 3 2021 doi: 10.1111 / vox.13221. Online ahead of print.


BACKGROUND AND OBJECTIVES: Blood donors are increasingly recognized as an information resource for surveillance. Our objective was to review severe acute respiratory syndrome coronavirus 2 seroprevalence studies conducted among blood donors to investigate methodological biases and to provide guidance for future research.

MATERIALS AND METHODS: We conducted a scoping review of peer-reviewed and preprinted publications between January 2020 and January 2021. Two reviewers used standardized forms to extract seroprevalence estimates and methodological data regarding l population sampling, periodicity, test characteristics and antibody kinetics. National data on cumulative incidence and social distancing policies were taken from publicly available sources and summarized.

RESULTS: Thirty-three studies representing 1,323,307 donated blood from 20 countries around the world were included (sample sizes ranged from 22 to 953,926 donations). The majority of studies (79%) reported seroprevalence rates

CONCLUSION: By the end of 2020, seroprevalence rates were far from reaching herd immunity. In addition to differences in community transmission and various public health policies, study designs and methodology were likely contributing factors to heterogeneity in seroprevalence.

PMID: 34862614 | DOI: 10.1111 / vox.13221

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