Society – Sociology Eso Science http://www.sociologyesoscience.com/ Tue, 12 Oct 2021 12:55:20 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://www.sociologyesoscience.com/wp-content/uploads/2021/06/favicon-6-150x150.png Society – Sociology Eso Science http://www.sociologyesoscience.com/ 32 32 CG Oncology to Present Two Programs at 2021 Society for Immunotherapy of Cancer (SITC) Annual Meeting https://www.sociologyesoscience.com/cg-oncology-to-present-two-programs-at-2021-society-for-immunotherapy-of-cancer-sitc-annual-meeting/ Tue, 12 Oct 2021 12:00:00 +0000 https://www.sociologyesoscience.com/cg-oncology-to-present-two-programs-at-2021-society-for-immunotherapy-of-cancer-sitc-annual-meeting/ IRVINE, Calif .– (COMMERCIAL THREAD) – CG Oncology, Inc., a clinical-stage biotechnology company focused on the development of oncolytic immunotherapies for patients with advanced cancer, today announced the acceptance of an oral presentation and a poster presentation at the Society for Immunotherapy of Cancer (SITC) Annual Meeting, held virtually and in person in Washington, DC, […]]]>

IRVINE, Calif .– (COMMERCIAL THREAD) – CG Oncology, Inc., a clinical-stage biotechnology company focused on the development of oncolytic immunotherapies for patients with advanced cancer, today announced the acceptance of an oral presentation and a poster presentation at the Society for Immunotherapy of Cancer (SITC) Annual Meeting, held virtually and in person in Washington, DC, November 10-14, 2021.

CG Oncology to present preliminary safety and efficacy data from CORE1, an ongoing Phase 2 clinical trial of CG0070 in combination with KEYTRUDA® (pembrolizumab), for the treatment of patients with non-invasive bladder cancer (NMIBC) not responding to Bacillus Calmette-Guérin (BCG).

In a previously announced clinical collaboration with Merck for the study of CG0070 used in combination with pembrolizumab, the goal of CORE1, which will enroll up to 35 patients, is to assess safety and efficacy. of CG0070 plus KEYTRUDA for the treatment of BCG-insensitive NMIBCs.

You can find more information about the study at www.clinicaltrials.gov (NCT04387461).

The details of the oral presentation are as follows:

CORE1: Single-arm, phase 2 study of CG0070 in combination with pembrolizumab in patients with non-invasive bladder cancer (NMIBC) unresponsive to Bacillus Calmette-Guérin (BCG)

Abstract Number: 955

Presenter: Roger Li, MD, Moffitt Cancer Center

Session date and time: Saturday, November 13, 2021 from 12:15 p.m. to 12:30 p.m. EST

Category: Last minute oral summary session

In addition, CG Oncology will present an overview of the design and methodology of the BOND3 trial, an ongoing global Phase 3 trial with CG0070 as monotherapy for the treatment of patients with NMIBC unresponsive to BCG. The objective of BOND3, which will recruit 110 patients, is to assess the safety and efficacy of CG0070 as monotherapy for the treatment of BCG-insensitive NMIBC.

You can find more information about the study at www.clinicaltrials.gov (NCT04452591).

The details of the poster presentation are as follows:

A single-arm, phase 3 study of CG0070 in subjects with non-muscle invasive bladder cancer (NMIBC) unresponsive to Bacillus Calmette-Guérin (BCG)

Abstract number: 426

Presenter: Edward Uchio, MD, UC Irvine Health, Department of Urology

Session date and time: Friday, November 12, 2021 and Saturday, November 13, 2021 from 7:00 a.m. to 8:30 p.m. EST

Category: Poster abstracts session

Full summaries of both presentations will be available on the SITC website on November 10, 2021.

About CG Oncology

CG Oncology is a clinical-stage biotechnology company focused on developing the next evolution in oncolytic immunotherapy for patients with advanced cancer. Our lead candidate, CG0070, is a selective oncolytic immunotherapy in a phase 3 trial with CG0070 as monotherapy for the treatment of BCG-insensitive NMIBC, and a combined phase 2 study of CG0070 with KEYTRUDA® (pembrolizumab) in the same indication. Other types of bladder cancer are being evaluated with CG0070 in combination with OPDIVO® (nivolumab), and additional indications in other solid tumors are being sought with CG0070 in combination with other endpoint inhibitors. immune control. At CG Oncology, we aim to take the next evolutionary step by providing innovative cancer care to millions of patients in need around the world. Learn more about www.cgoncology.com.


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River-to River Trail Society Announces Fall Hiking Schedule | https://www.sociologyesoscience.com/river-to-river-trail-society-announces-fall-hiking-schedule/ Mon, 11 Oct 2021 05:00:00 +0000 https://www.sociologyesoscience.com/river-to-river-trail-society-announces-fall-hiking-schedule/ The River-to-River Trail Society is offering a series of guided hikes this fall in and near the Shawnee National Forest. All hikes are free and open to the public. Although the hikes vary in difficulty, all are aimed at healthy people who have already hiked. Trekking poles and boots or sturdy shoes are highly recommended. […]]]>

The River-to-River Trail Society is offering a series of guided hikes this fall in and near the Shawnee National Forest.

All hikes are free and open to the public. Although the hikes vary in difficulty, all are aimed at healthy people who have already hiked. Trekking poles and boots or sturdy shoes are highly recommended. All hikers must bring their own water and a snack. No dogs, please.

To protect the health of leaders and hikers, all hikes will be either loop or round trip so as not to require public transport. All hikers will be responsible for getting to the trailhead and all will be required to sign a liability waiver.

Whenever possible, social distancing is expected and, where appropriate, masks are recommended. All other conditions required by decree of the governor or recommendations of the CDC must be met.

The company’s second hike will take place on Saturday, October 16 in the Win Towers area of ​​Gallatin and Hardin counties. The president of the company, Bill Gilmour, will be the leader. Hikers should meet at 10 a.m. at the Knights of the Golden Circle parking lot, east of Forest Road, three-quarters of a mile north of the entrance to the Garden of the Gods. Forest Road is closed north of the parking lot, so hikers should approach from the south.

For the third hike on Saturday, October 23, Chris Drone will lead a hike at Ferne Clyffe State Park in Johnson County. Hikers should meet at 10 a.m. at the parking lot near the main waterfall trailhead.

The fourth hike will take place on Saturday, October 30 at Dutchman Lake in Johnson County. Bill Gilmour will lead. Meet at 10 a.m. at the Dutchman lake parking lot.

On Saturday, November 6, Fred Scott will lead the company’s fifth hike in the High Knob area of ​​County Gallatin on Trails 153, 180, 180C and 185, as well as part of the River-to-River Trail. Hikers are to meet at 10 am in the parking lot at the top of High Knob; drive slowly through the horse campsite.

On Saturday, November 13, Mart Watson will lead a hike in Pope County, west of Jackson Hollow and Cove Hollow, an area known to climbers as “the Promised Land”. Hikers are to meet at 10 a.m. at the East Trigg Trailhead on the east side of Trigg Tower Road, one mile north of Trigg Tower and approximately 4 miles northeast of Simpson.

The last scheduled hike of the year by the company will take place on Saturday, November 27. Gillum and Vicki Ferguson will lead a post-Thanksgiving hike to a location to be announced later.

The River-to-River Trail is a hiking and horseback riding trail that stretches 157 miles through southern Illinois between Elizabethtown on the Ohio River and Grand Tower on the Mississippi. The River-to-River Trail Society is an Illinois nonprofit, founded by John O’Dell in 1993. All of its work is done by unpaid volunteers. In addition to its free public hiking program, the company engages in trail maintenance and defense and publishes an online guide to the entire River-to-River trail, which can be downloaded for free from the site. Company web. rivertorivertrail.net. Patches for the Society can be purchased for $ 5 during the Society’s Public Hikes.


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Dixon Historical Society meeting to focus on town’s dairy history – The Vacaville Reporter https://www.sociologyesoscience.com/dixon-historical-society-meeting-to-focus-on-towns-dairy-history-the-vacaville-reporter/ Sat, 09 Oct 2021 22:49:38 +0000 https://www.sociologyesoscience.com/dixon-historical-society-meeting-to-focus-on-towns-dairy-history-the-vacaville-reporter/ Dixon’s past as a major dairy town will be the subject of the Dixon Historical Society meeting next week. According to a press release, Dixon was nicknamed “Dairy City” by Sunset magazine in 1914 due to its abundance of dairy farms. Immigrants from places such as Germany, Portugal, Switzerland and Ireland came to Dixon because […]]]>

Dixon’s past as a major dairy town will be the subject of the Dixon Historical Society meeting next week.

According to a press release, Dixon was nicknamed “Dairy City” by Sunset magazine in 1914 due to its abundance of dairy farms. Immigrants from places such as Germany, Portugal, Switzerland and Ireland came to Dixon because they found its temperate climate with mild winters and sufficient rains to be well suited for producing alfalfa. intended to feed cows in the dairy manufacturing process. Local dairy farms supplied milk and dairy products to the Dixonites as well as to surrounding areas of Sacramento and the Bay Area, where products were delivered by trucks and trains and kept cool with ice.

The reunion will feature stories shared by the descendants of Dixon dairy farmers about what it was like growing up on a dairy farm. Speakers will include Bill Hull and Cathy Hull Jones, Stuart Rowe, Carol and Rick Sequieria, Dr Peter Timm and Jeanie Vanetti.

Afterwards, President Bill Schroeder will lead regular activities, including an update on the Dixon History Museum and the Officer Showcase 2022-2024.

The meeting will be held from 2:00 p.m. to 4:30 p.m. on October 17 at Dixon United Methodist Church, 209 N. Jefferson St. Guests are welcome to attend. Masks will be encouraged and chairs will be spaced to comply with COVID-19 guidelines.


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Hardin County Agricultural Society holds meeting in October – WKTN https://www.sociologyesoscience.com/hardin-county-agricultural-society-holds-meeting-in-october-wktn/ Fri, 08 Oct 2021 18:21:12 +0000 https://www.sociologyesoscience.com/hardin-county-agricultural-society-holds-meeting-in-october-wktn/ The Hardin County Agricultural Society met on Wednesday, October 6, 2021 for the October monthly board meeting. Thirteen directors and seven guests were present. Brad Murphy, vice chairman of the board, opened the meeting. Nathan Weaver has said he will be running for the Goshen Twp. Director.Jami Dellifield, OSU Extension, provided an update on the […]]]>

The Hardin County Agricultural Society met on Wednesday, October 6, 2021 for the October monthly board meeting. Thirteen directors and seven guests were present.

Brad Murphy, vice chairman of the board, opened the meeting.

Nathan Weaver has said he will be running for the Goshen Twp. Director.
Jami Dellifield, OSU Extension, provided an update on the Carcass Show.
Roger Crowe, Hardin County Commissioner, said they were still working on COVID relief money.

In correspondence, thank you cards were read by Cain Sullivan and Wyatt Brown. A letter on the Carcass Show was read by Mark Badertscher. There were 2 correspondence regarding the 2021 Fair read by Steve Holbrook and Robin Hughes.

Brad Murphy, chairman of the executive committee, spoke about giving extra beef to office staff. The board agreed to give Kolt Buchenroth, Catherine Osborne, Randy Clark and Doris Ralston one beef each, then Judi Cronley and Pete Fout would each get ½ beef.

It was noted that there had been good constructive reviews for the development of a multi-purpose facility at the exhibition grounds.

Rob Wilson, co-superintendent of the field committee, said winter indoor storage has started. It’s $ 25 per month for vehicles and $ 10 per linear foot for boats, trailers, RVs, RVs, etc. Administrators were told to start taking inventory of their buildings for insurance purposes. The board agreed to pay the Hardin Northern and Kenton FFAs $ 150 each for helping stack the benches after the fair was over.

Rob Wilson, president of animation, discussed moving the drag races to Thursday night of the fair, allowing the harness races to take place over 2 days. Harness races would take place on Wednesday evening and Thursday afternoon. The managers seemed to agree with this suggestion. Everyone was happy with how well the rodeo went this year.

Jack McBride and Judi Cronley provided an update on the JR Fair Livestock Sale. He was very successful this year. Profit was about $ 100,000 more than last year. Total sales were $ 453,359. There were 304 buyers. Cattle sales checks will be sent out when the majority of buyers have paid, there are still 79 buyers who owe $ 122,409. Hopefully the kids can start collecting their checks by the end of the month.

Brad Murphy, president of the dealership and suppliers, said Durant Amusements plans to redesign the Midway with more options available. It was noted that the profits from the Grange and Hardin Northern restaurants have still not been received.

It was noted that the publicity / sponsorship committee is due to meet soon and discuss their budget request for the 2022 show.

Under former profession:

Membership $ 2.00 additional to season tickets can still be purchased until October 15th. The Open Class and Jr Class Premium vouchers were sent to everyone except the exhibitors of JR Fair Livestock. Petitions for the November election for Fair Trustees must be filed by Friday, October 29 at 4 p.m. In election this year: Dudley, Goshen, Lynn, Roundhead, Washington Twp.’s and 2 directors in important positions. Plus, a manager is still needed for Taylor Creek Twp. for a 2-year term. Anyone wishing to run for one of these director positions must have a 2021 membership ticket. Anyone interested in a petition must go to the secretariat to pick up a petition before Wednesday, October 13 at 4:00 p.m. Then, the petition must be returned by Friday, October 29 at 4 p.m.

In the context of new business:

The dates for the 2022 fair are requested from the Ohio Department of Agriculture from September 6 to 11. Matt Jennings has been nominated as an Outstanding Fan of the 2021 Fair. He will be honored on Friday, January 7, 2022 at the Ohio Fair Manager’s Convention in Columbus. The board of directors has agreed to request money from the Ohio Fairs Fund 2022. Jack McBride and Brad Murphy have been appointed as delegates to the Fair’s board of directors at the OFMA convention. It was noted that the fair’s board of directors currently has 11 directors and employees who stay overnight during the congress. It was noted that the annual members’ meeting and the fair’s board reorganization meeting are scheduled for Saturday, November 6 at 7:30 p.m. in the community building. The annual election of the director of the fair board is scheduled for Saturday, November 6 from 3 p.m. to 7 p.m. at the fair board office. Jack McBride, Grant Mizek, Jake McFadden, Christa Rarey and Dan Beale volunteered to be the judges and clerks of the election. The directors decided to have a fair closing meeting on Wednesday October 20 at 6 p.m. in the community building. and a book review from the fair will take place on Wednesday, October 27 at 6 p.m. in the Community Bldg. Judi Cronley said the district meeting is set for Thursday, November 4 at 7 p.m. at the Auglaize County Fairgrounds.

The next meeting of the Council of the Fair is scheduled for Wednesday 3 November at 7 p.m.



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Hong Kong civil society continues to shrink https://www.sociologyesoscience.com/hong-kong-civil-society-continues-to-shrink/ Thu, 07 Oct 2021 08:16:34 +0000 https://www.sociologyesoscience.com/hong-kong-civil-society-continues-to-shrink/ BANGKOK – After a widespread crackdown on pro-democracy opposition in Hong Kong that saw dozens of activists arrested and jailed, authorities have firmly turned their attention to civil society groups in the city. In recent months, several of Hong Kong’s main opposition groups have disbanded as crackdowns mount in the city. Following the 2019 anti-government […]]]>

After a widespread crackdown on pro-democracy opposition in Hong Kong that saw dozens of activists arrested and jailed, authorities have firmly turned their attention to civil society groups in the city.

In recent months, several of Hong Kong’s main opposition groups have disbanded as crackdowns mount in the city.

Following the 2019 anti-government protests, Beijing implemented sweeping national security legislation prohibiting acts such as secession, subversion, and collusion with foreign forces. Hong Kong’s pro-democracy movement has been stifled as street protests have come to a halt and political speeches that Beijing deems offensive have been banned.

Since the security law came into force last year, at least 50 civil society groups have retreated, Agence France-Presse reports.

October 1 marked the 72nd anniversary of the People’s Republic of China, a public holiday and a day of national celebrations in China. But in Hong Kong, pro-democracy activists have historically used the day to launch street protests and call for political reforms. This year, only a handful of protesters gathered in the streets and were arrested by authorities. Reports say as many as 8,000 police officers were on standby all day.

In previous years, China’s National Day occupied Hong Kong civil society groups.

The Civil Human Rights Front, founded in 2002, was behind the largest protest ever in Hong Kong, which drew nearly 2 million people in June 2019. The group typically held protests on important dates in the year. city ​​political calendar. But the organization disbanded in August after being accused of violating Hong Kong’s national security law.

The Hong Kong Alliance for the Support of the Democratic Patriotic Movements of China was once responsible for organizing the annual candlelight vigil in Hong Kong on June 4 in memory of the Tiananmen Square crackdown in Beijing in 1989, an event which usually attracted thousands of people.

But the alliance folded in September, ending 32 years of activism, when three leaders were jailed, facing a number of charges, including inciting secession.

Political analyst Joseph Cheng, formerly in Hong Kong but now based in New Zealand, praised the group but admitted there was no more “room for survival” for opposition groups from Hong Kong.

“The alliance probably has more symbolic value in that its formation in 1989 led to the formation of pro-democracy parties immediately after. Its continued operation after (the transfer of Hong Kong from Britain to China in) 1997 was seen as a symbol of the tolerance of the “one country, two systems” model, ”he told VOA.

Hang Tung-chow, the former vice chairman of the Hong Kong alliance and one of three leaders currently in prison, told VOA in August that opposition groups could still survive in the city, at least. informally.

“I think there will probably be more decentralized clusters, connection platforms, which might have difficulty seeing very open organizations and public events. But below the surface, underground, there will always be a connection there and organizations going, ”she said.

Eric Yan-ho Lai, author of the book Unraveling the authoritarian rule of law in Hong Kong, told VOA that there were already signs of the sustainability of civil societies.

“We can also see this year that in many cases, people will come together to collect collectively to support certain pro-democracy shops or traders, or they will collectively attend court hearings (in) solidarity with the protesters. I would say that these would be possible traces that local people are willing to support the development of civil society in this way, ”he said.

He added: “They won’t be very visible to the public, (or) eye-catching.”

The erosion of civil society continued in October, with the dissolution of Hong Kong’s largest independent union.

The Hong Kong Trade Union Confederations were formed in 1990 and this year had 145,000 members. But the group voted on Oct. 3 to disband after some members received threats to their personal safety.

Lai, who is also a political analyst, said China is likely to use pro-Beijing groups to fill the civil society void in the city.

“The (pro-Beijing) Federation of Trade Unions, (which) now claims to be (as) the largest (strongest) union coalition in Hong Kong since the suspension of the Confederation of Trade Unions,” Lai said. “China could continue to establish and train its own support groups within civil society. So, it is also a way, like mainland China, to allow so-called organizations and groups in society, but they are regulated or monitored or even controlled by the Communist Party (Chinese).

Other groups have also had to disband in Hong Kong’s changing social and political environment.

After 48 years, the Hong Kong Professional Teachers Union came to an end following strong criticism from Chinese state media and the government, which claimed the union had dragged schools into politics.

Local Hong Kong media reported on Thursday that the Chinese University of Hong King’s student union had also dissolved.

And the youth group Student Politicism shut down in September after just 16 months after the arrest under National Security Law of the group’s leaders, including activist Wong Yat-chin.

Hong Kong Managing Director Carrie Lam denied that there is a crackdown on civil societies.

In his annual political speech on Wednesday, Lam said that Hong Kong’s national security legislation “back on track”As the city“ entered a new era ”.

But with the space for civil society shrinking, concerns remain about other Hong Kong organizations that Beijing opposes.

The Hong Kong Journalists Association, (HKJA), the city’s main news group, has been repeatedly criticized by the Chinese state-controlled media, as well as by the Hong Kong authorities, claiming it was biased and “anti-government”.

Ronson Chan, chairman of the HKJA, told VOA in an interview last month that the organization would not resign, but he admits the pressure is on any group targeted by Beijing.

“After the national security law, everyone knows there are a lot of red lines, but nobody knows how the red lines work,” he said.


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Bethel Park Historical Society Project Donations Surpass $ 1 Million | New https://www.sociologyesoscience.com/bethel-park-historical-society-project-donations-surpass-1-million-new/ Wed, 06 Oct 2021 19:09:07 +0000 https://www.sociologyesoscience.com/bethel-park-historical-society-project-donations-surpass-1-million-new/ Five years ago this month, the Bethel Park Historical Society embarked on fundraising to renovate the South Park Road building, originally built as a high school in 1905. “We have set a goal of one million dollars,” said Tim Moury, president of the historical society. “People looked at us – even we looked at each […]]]>

Five years ago this month, the Bethel Park Historical Society embarked on fundraising to renovate the South Park Road building, originally built as a high school in 1905.

“We have set a goal of one million dollars,” said Tim Moury, president of the historical society. “People looked at us – even we looked at each other – saying, what do you think the odds are? Can we do it? “






Tim Moury



At an October 3 open house in the building, he announced that the historical society had received a $ 10,000 grant from the Bethel Park Community Foundation.

“Between donations, fundraising and in-kind services, our total dollar amount is one million eight thousand dollars,” he said. “It’s really amazing how much the community has been supportive of our project. “

Local residents certainly supported the open house, nearly filling the old renovated upstairs classroom that was dedicated during the event as the Community Foundation auditorium.

The Secretary of the Historical Society, Bill Haberthur, provided an update of additional improvements that have occurred over the past two years.

“We haven’t let a small pandemic stop our progress,” he laughed.

For example, the original bell was placed in a dome atop the roof of what is now known as the Schoolhouse Arts and History Center. In fact, the ringing of the bell marked the start of the open house, just like it would be a school day.






Johno prascak

Artist Johno Prascak with his eight-canvas, 32-foot painting “Carnegie Steel – Homestead Works, 1926”, on display at the Schoolhouse Arts and History Center



The historical society received a grant of $ 170,000 for the modernization of the heating, ventilation and air conditioning system, and the work is nearing completion, Haberthur said. The electrical system has gone from fuses to circuit breakers, and more toilets are now available for visitors.

The 11 exterior doors have been replaced and over the next few weeks the building will receive new gutters and downspouts.

“Not only have we made renovations, but we have greatly enriched our collection,” said Haberthur, as donations of items continue to increase the historical society’s presentation of local memorabilia related to education, to the army, coal mining and other areas of interest.

The Community Foundation grant-funded project, “Raise the Flag,” involves moving the former St. Valentine School flag pole, which was dedicated by foreign war veterans in 1961, to the center of art and history.

“It’s probably more cost effective to buy a new one than to move the old one, but we’re here to preserve history,” Moury said.

Another fundraising effort, coordinated by society members Jim and Lisa Jenkins, was the sale of trees to be planted along the Park Avenue side of the building.

“We did this to really put it back to where it was when this building was originally built,” Moury said. “If you go back and look at the first photos, it was a tree-lined street.”

On the open house, those who made the purchases received engraved plaques to place in front of their designated trees.

South Side Slopes performers Johno Prascak and his wife, Maria DeSimone Prascak, longtime supporters of the historic society’s efforts, attended the event.

Johno exhibited his 32-foot painting “Carnegie Steel – Homestead Works, 1926” and Maria his watercolor from the Schoolhouse Arts and History Center, with prints available for sale to benefit the company.

Also present was State Representative Natalie Mihalek, from the Township of R-Peters, whose district includes part of Bethel Park. Moury acknowledged his efforts to help secure grants on behalf of the Schoolhouse Arts and History Center.

“It’s such an asset to the community. I can’t communicate it enough. And what a small role I can play to help divert some of the available public funds, ”said Mihalek,“ I’m happy to do so. I think it’s just a treasure for Bethel Park.






Janet Furtney and Jim Jenkins

Janet Furtney, who owns and operates the Improvement Thru Movement Dance Studio at the Schoolhouse Arts and History Center, watches Jim Jenkins assemble a stand for the plaque to place on his tree.




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NOXXON Pharma Announces Upcoming Oral Presentation at 2021 Society for Neuro-Oncology Annual Meeting https://www.sociologyesoscience.com/noxxon-pharma-announces-upcoming-oral-presentation-at-2021-society-for-neuro-oncology-annual-meeting/ Wed, 06 Oct 2021 06:00:00 +0000 https://www.sociologyesoscience.com/noxxon-pharma-announces-upcoming-oral-presentation-at-2021-society-for-neuro-oncology-annual-meeting/ BERLIN–(COMMERCIAL THREAD) – Regulatory news: NOXXON Pharma SA (Euronext Growth Paris: ALNOX), a biotechnology company focused on improving cancer treatments by targeting the tumor microenvironment (TME), announces that new data from the ongoing GLORIA Phase I / II trial in brain cancer will be presented by the Dr. Frank Giordano, principal investigator of the study, […]]]>

BERLIN–(COMMERCIAL THREAD) – Regulatory news:

NOXXON Pharma SA (Euronext Growth Paris: ALNOX), a biotechnology company focused on improving cancer treatments by targeting the tumor microenvironment (TME), announces that new data from the ongoing GLORIA Phase I / II trial in brain cancer will be presented by the Dr. Frank Giordano, principal investigator of the study, in an oral presentation at the annual meeting of the Society for Neuro-Oncology. The meeting will take place in Boston, Massachusetts, United States, from November 18-21, 2021.

The details of the oral presentation are as follows:

Title: Inhibition of CXCL12 in Unmethylated MGMT Glioblastoma – Results of an Early Proof of Concept Assessment in the Multicenter Phase I / II GLORIA Trial (NCT04121455)

Session title: Session summary: Clinical trials I

Date of the session: Friday, November 19, 2021

Presentation time: 5:00 p.m. – 5:05 p.m. EST / 11:00 a.m. – 11:05 p.m. CET

Presenter: Dr Frank Giordano, Director and Chairman of the Radiation Oncology Department at the University Hospital Bonn, Germany

The embargo for abstracts published in the 2021 Abstract Supplement of the Official Journal of SNO Neuro-Oncology will be lifted at 7:00 a.m. EST on Thursday, November 11, 2021 and the abstract will be available at: https://academic.oup.com/neuro-oncologie.

To register for the event, please click here.

A copy of the presentation will be available at NOXXON website shortly after the event.

About NOXXON

NOXXON’s oncology-focused pipeline acts on the tumor microenvironment (TME) and the cancer immunity cycle by breaking down the tumor protective barrier and blocking tumor repair. By neutralizing the chemokines in TME, NOXXON’s approach works in combination with other forms of treatment to weaken tumor defenses against the immune system and allow greater therapeutic impact. NOXXON’s main program, NOX-A12, provided the final revenue data of a Keytruda® combined trial in patients with metastatic colorectal and pancreatic cancer published at the ESMO conference in September 2020 and July 2021, the company announced its phase 2 study, OPTIMUS, to further assess safety and efficacy NOX-A12 in combination with Keytruda from Merck® and two different chemotherapy regimens as second-line treatment in patients with metastatic pancreatic cancer. NOXXON is also studying NOX-A12 in brain cancer in combination with radiation therapy, which has been granted orphan drug status in the US and EU for the treatment of certain brain cancers. GLORIA, a trial of NOX-A12 in combination with radiotherapy in patients with newly diagnosed brain cancer who will not clinically benefit from standard chemotherapy, provided interim data from the first two cohorts showing consistent tumor reductions and objective tumor responses. The company’s second clinical-stage active, NOX-E36, is a phase 2 TME active targeting the innate immune system. NOXXON plans to test NOX-E36 in patients with solid tumors. Further information can be found at: www.noxxon.com.

Keytruda® is a registered trademark of Merck Sharp & Dohme Corp

Visit NOXXON on LinkedIn and Twitter

About the GLORIA study

GLORIA (NCT04121455) is the phase 1/2 dose escalation study of NOXXON of NOX-A12 in combination with irradiation in patients with first-line glioblastoma (brain cancer) with a non-MGMT promoter. methylated (resistant to standard chemotherapy).

About the OPTIMUS study

OPTIMUS (NCT04901741) is NOXXON’s open-label, two-arm phase 2 study of NOX-A12 in combination with pembrolizumab and nanoliposomal irinotecan / 5-FU / leucovorin or gemcitabine / nab-paclitaxel in patients with ‘stable microsatellite metastatic pancreatic cancer.

Disclaimer

Certain statements in this communication contain wording or terms that refer to future or future developments, as well as negations of such wordings or terms, or similar terminology. These are described as forward-looking statements. In addition, all information contained in this communication concerning the expected or future results of the business segments, financial indicators, changes in the financial situation or other financial or statistical data contains such forward-looking statements. The company cautions potential investors not to rely on such forward-looking statements as certain predictions of actual future events and developments. The company is neither responsible nor liable for updating this information, which only represents the inventory on the day of publication.



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Thomaston Historical Society receives bicentennial grant – Knox County VillageSoup https://www.sociologyesoscience.com/thomaston-historical-society-receives-bicentennial-grant-knox-county-villagesoup/ Tue, 05 Oct 2021 18:45:10 +0000 https://www.sociologyesoscience.com/thomaston-historical-society-receives-bicentennial-grant-knox-county-villagesoup/ THOMASTON – The Thomaston Historical Society has announced its selection by the Maine Bicentennial Commission to receive grant funds to celebrate 200 years of shipbuilding in the city. Susan Devlin of the Thomaston Historical Society said she was very proud of the society’s accomplishments for this grant, including the efforts of local historian Peggy McCrea. […]]]>

THOMASTON – The Thomaston Historical Society has announced its selection by the Maine Bicentennial Commission to receive grant funds to celebrate 200 years of shipbuilding in the city.

Susan Devlin of the Thomaston Historical Society said she was very proud of the society’s accomplishments for this grant, including the efforts of local historian Peggy McCrea.

Grant funds were used for three items: a large plaque commemorating the history of Thomaston shipbuilding; a 16-page color booklet on Thomaston shipyards and shipbuilders; 10 large color posters featuring shipyard owners and builders.

The plaque measures 63 inches by 48 inches and was placed at the Thomaston Public Landing Overlook. It shows an 1855 map of the city and lists the location of 12 major shipyards and their owners.

Lowe’s Home Improvement of Thomaston provided the framing and Thomaston’s Public Works Department installed the plaque. It was inaugurated in August during a small inauguration ceremony with city officials.

The booklet, “The City That Sailed: Major Thomaston Shipyards and Shipbuilders,” features photos from the Thomaston Historical Society, information on 10 Thomaston shipyards, and examples of ships built in the city.

This free booklet is available at the plaque, the municipal office, and the Thomaston Historical Society, located at 80 Knox St.

The 10 framed posters show different local shipyard owners and builders and their contributions to the shipbuilding industry.

These posters begin with Captain Edward Robinson, an American representative born in Cushing in 1796. Robinson was a prominent resident and shipbuilder until his death in 1857.

The most recent posters include Cabot and Drew Lyman, who still build ships at Lyman Morse.

These posters are currently on display in the main lobby of the Thomaston Municipal Building on Valley Street. This is the first exhibit to be placed in the Thomaston Historical Society’s new satellite gallery in the municipal building, which was erected through donations from Brooks Trap Mill and Lowe’s of Thomaston.

Posters are available for travel to other sites as an exhibit. Interested parties can contact the Thomaston Historical Society at 354-2295.

Thomaston Town Manager Kara George unveils the shipbuilding plaque commemorating 200 years of the industry. Photo by Jeremy George

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Facebook “tears our societies apart”: key excerpts from a whistleblower | Facebook https://www.sociologyesoscience.com/facebook-tears-our-societies-apart-key-excerpts-from-a-whistleblower-facebook/ Mon, 04 Oct 2021 23:30:00 +0000 https://www.sociologyesoscience.com/facebook-tears-our-societies-apart-key-excerpts-from-a-whistleblower-facebook/ Frances Haugen’s interview with the US news program 60 Minutes contained a litany of damning statements on Facebook. Haugen, a former Facebook employee who joined the company to help it fight disinformation, told CBS that the tech company prioritizes profit over security and “is tearing our societies apart.” Haugen will testify in Washington on Tuesday, […]]]>

Frances Haugen’s interview with the US news program 60 Minutes contained a litany of damning statements on Facebook. Haugen, a former Facebook employee who joined the company to help it fight disinformation, told CBS that the tech company prioritizes profit over security and “is tearing our societies apart.”

Haugen will testify in Washington on Tuesday, as political pressure intensifies on Facebook. Here are some key excerpts from Haugen’s interview.

Prioritize profit over public good

Haugen’s sharpest words echoed what is becoming a regular refrain from politicians on both sides of the Atlantic: that Facebook puts profit before the well-being of its users and the public.

“What I saw over and over on Facebook was that there were conflicts of interest between what was good for the public and what was good for Facebook. And Facebook, over and over again, has chose to optimize for his own interests, such as earning more money.

She also accused Facebook of endangering public safety by reversing changes to its algorithm after the 2020 presidential election is over, allowing misinformation to spread again on the platform. “And as soon as the elections were over, they turned them over [the safety systems] go back or they’ve brought the settings back to what they were before, to prioritize growth over safety. And that really sounds like a betrayal of democracy to me. “

Facebook’s approach to security compared to others

During a 15-year career as a tech professional, Haugen, 37, has worked for companies like Google and Pinterest, but said Facebook has the worst approach to restricting harmful content. She said: “I saw a bunch of social media and it was a lot worse on Facebook than anything I had seen before.” Referring to Mark Zuckerberg, founder and CEO of Facebook, she said, “I have a lot of empathy for Mark. And Mark never set out to create a hate platform. But it has made it possible to make choices where the side effects of those choices are that hateful and polarizing content gets more distribution and more reach. “

Instagram and mental health

Instagram logo. Photograph: Dado Ruvić / Reuters

The most impactful document leak was a series of research slides that showed Facebook’s Instagram app was harming the mental health and well-being of some teenage users, with 32% of teenage girls believing it to be. worsened their body dissatisfaction.

She said, “And what’s super tragic is Facebook’s own research, as these young women start consuming this eating disorder content, they’re getting more and more depressed. And that actually encourages them to use the app more. And so, they find themselves in this feedback cycle where they hate their bodies more and more. Facebook’s own research indicates that it’s not just that Instagram is dangerous for teens, that it harms teens, it’s significantly worse than other forms of social media.

Facebook described the Wall Street Journal reports on the slides as a “misrepresentation” of its research.

Why Haugen leaked the documents

Haugen said “person after person” tried to fix Facebook’s problems but was crushed. “Imagine you know what’s going on inside Facebook and no one outside. I knew what my future would look like if I continued to stay inside Facebook, which person after person is tackling this inside Facebook and getting down to the ground.

Having joined the company in 2019, Haugen said she decided to take action this year and started copying tens of thousands of documents from Facebook’s internal system, which she says shows Facebook is not doing , despite public comments to the contrary, significant progress in the fight online. hatred and misinformation. “At one point in 2021, I realized, ‘OK, I’m going to have to do this systemically, and I have to get out enough that no one can question that this is real. “”

Facebook and violence

Facebook logo.
Facebook logo. Photograph: Dado Ruvić / Reuters

Haugen said the company contributed to ethnic violence, a reference to Burma. In 2018, following the massacre of Rohingya Muslims by the military, Facebook admitted that its platform had been used to “foment division and incite offline violence” concerning the country. Speaking on 60 Minutes, Haugen said: “When we live in an information environment filled with angry, hateful and polarizing content, it erodes our civic trust, it erodes our faith in each other, it erodes our ability. to want to take care of each other The version of Facebook that exists today is tearing our societies apart and causing ethnic violence in the world.

Facebook and the Washington riot

The January 6 riot, when crowds of right-wing protesters stormed the Capitol, came after Facebook disbanded the civic integrity team of which Haugen was a member. The team, which focused on election-related issues around the world, was dispersed to other Facebook units in the wake of the US presidential election. “They told us, ‘We are dissolving civic integrity.’ Like, basically, they said, ‘Oh well, we’ve passed the election. There were no riots. We can get rid of civic integrity now. Fast forward a few months we had the insurgency. And when they got rid of civic integrity, that’s when I was like, “I don’t believe they’re willing to invest what needs to be invested to keep Facebook from being dangerous. . “

The 2018 algorithm change

Facebook has changed the algorithm of its news feed – Facebook’s central feature, which provides users with a personalized feed of content such as photos of friends and news – to prioritize content that increases engagement. users. Haugen said this makes the controversial content more important.

“One of the consequences of how Facebook selects this content today is that it optimizes content that elicits engagement or reaction. But his own research shows that content that is hateful, that divides, that polarizes – it’s easier to inspire people with anger than other emotions. She added, “Facebook has realized that if they change the algorithm to be more secure, people will spend less time on the site, they will click less ads, they will earn less money.

Haugen said European political parties have reached out to Facebook to say the change in news feed is forcing them to take more extreme political positions in order to gain users’ attention. Describing the concerns of politicians, she said: “You are forcing us to take positions that we don’t like, that we know are bad for society. We know that if we don’t take these positions, we won’t win in the social media market.

In a statement to 60 Minutes, Facebook said, “Every day, our teams must balance protecting the right of billions of people to speak out openly with the need to keep our platform a safe and positive place. make significant improvements to combat the spread of disinformation and harmful content. To suggest that we encourage bad content and do nothing is just not true. If research had identified an exact solution to these complex challenges , the tech industry, governments and society would have solved them a long time ago. ”


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Société Saint-Vincent-de-Paul gains a new director while the number of volunteers remains low | Local News https://www.sociologyesoscience.com/societe-saint-vincent-de-paul-gains-a-new-director-while-the-number-of-volunteers-remains-low-local-news/ Mon, 04 Oct 2021 04:15:00 +0000 https://www.sociologyesoscience.com/societe-saint-vincent-de-paul-gains-a-new-director-while-the-number-of-volunteers-remains-low-local-news/ The new director of the Saint Vincent de Paul Society of Uniontown embraces the society’s mission to help those in need. But, said director Bernadette Oberlechner, to continue providing assistance, the association also needs help. “We could probably use 50 to 100 volunteers,” Oberlechner said, adding that they were starting a volunteer campaign with information […]]]>

The new director of the Saint Vincent de Paul Society of Uniontown embraces the society’s mission to help those in need.

But, said director Bernadette Oberlechner, to continue providing assistance, the association also needs help.

“We could probably use 50 to 100 volunteers,” Oberlechner said, adding that they were starting a volunteer campaign with information in 4,000 church bulletins in the area.

Oberlechner began on September 21 and found the organization was struggling with a shortage of volunteers, an issue that began last year during the pandemic.

“We just don’t have enough,” said Sheryl Dennis, volunteer and volunteer coordinator for the Society of Saint Vincent de Paul in Uniontown.

Dennis said COVID-19 has harmed a lot of different places and made people afraid to volunteer, even though safety measures are in place.

The organization lost more than half of its volunteers during the pandemic. Dennis said it hits those who stay hard, trying to keep up with sorting and pricing of items in the store, helping in the pantry or delivering furniture.

“We continue to do the same,” she said. “It’s just that we can do the same. “

Oberlechner said volunteers can set their own schedules, work in whatever area they want and set their own schedules.

“It can be a fun experience,” Oberlechner said. “Some people like it for the social aspect of it.”

“When you volunteer here you meet a lot of nice people,” Dennis said. “I made a lot of good friends here that I didn’t think I made, and you don’t have to be Catholic to volunteer here.”

Although the shortage of volunteers is a challenge, Oberlechner said she was excited to take on the role of director of St. Vincent de Paul in Uniontown.

“I love what they do, I love the goal and I love the mission,” said

The organization offers help in a number of ways, including emergency aid, a pantry, through its thrift store and by working with Hear Fayette, an advocacy group for people who are hard of hearing or hard of hearing.

Oberlechner was at church when she saw in the newsletter that the association was looking for a director of operations.

“I felt it was a call from God,” she said. “I prayed every day. I applied for the same position three years ago, so timing is of the essence.

Anyone interested in volunteering can do so by calling 724-439-9188 or stopping to fill out an application at 62-70-90 N. Mount Vernon Ave., Uniontown.


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